Project title
開發具高同功酵素專一性之抗第二型拓撲異構脢抗癌藥物---(子計畫二)系統性篩選鑑定DNA拓樸脢alpha異構脢的專一性藥物(I)
Internal ID
NSC100-2325-B002-019
Principal Investigator
Start Date
May 1, 2011
End Date
April 12, 2012
Partner Organizations
Project Web Site
Systematic Identification of DNA Topoisomerase II alpha-Specific Targeting Agents (I)
Keywords
第二型拓樸酵素抑制劑
抗癌藥物
蛋白-藥物-DNA三重複合體
DNA topoisomerase
topoisomerase-targeting therapy
isozyme-specific agents
topoisomerase cleavable complex
mutagenesis
carcinogenesis.