Project title
牙髓幹細胞釋放物質中基質金屬蛋白酶組織抑制劑於蜘蛛網膜下腔出血後保護血腦障壁破壞的角色探討
Internal ID
MOST111-2314-B002-254-MY2
Principal Investigator
Start Date
August 1, 2022
End Date
July 31, 2023
Investigators
Partner Organizations
Dental Pulp Stem Cell-Derived Factors Attenuates Blood-Brain Barrier Disruption after Subarachnoid Hemorrhage: Role of Timp-1–Mediated Mmp-Dependent and Independent Mechanisms
Keywords
Subarachnoid hemorrhage
microcirculation
blood-brain barrier
dental pulp stem cell
conditioned medium
insulin-like growth factor-1
matrix metalloproteinase
tissue inhibitors of metalloproteinases
Description
本計畫將利用細胞與動物模式，針對牙髓幹細胞所分泌之條件培養液進行一系列的分析，針對其中改善蜘蛛膜下腔出血微血循環的關鍵物質之一―基質金屬蛋白酶組織抑制劑，以及研究其作用之細胞與分子機制。希望透過執行本計畫釐清牙髓幹細胞釋放物質治療機轉，期望透過精準的了解牙髓幹細胞釋放物質保護機制，提供出血性中風及其他神經性發炎相關疾病一個藥物開發標並對臨床治療有所幫助