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.National Taiwan University / 國立臺灣大學
Project / 研究計畫
The Role of Different Forms of Interleukin-15 in Disseminated Ovarian Cancer Hosts Undergoing Chemotherapy: Focus on the Regulation of Immune Checkpoint = 探討不同形式之介白素15在瀰漫性卵巢癌宿主接受化療藥物治療後的影響:著重於免疫檢查點的調控
The Role of Different Forms of Interleukin-15 in Disseminated Ovarian Cancer Hosts Undergoing Chemotherapy: Focus on the Regulation of Immune Checkpoint = 探討不同形式之介白素15在瀰漫性卵巢癌宿主接受化療藥物治療後的影響:著重於免疫檢查點的調控
Details
Primary Data
Project title
探討不同形式之介白素15在瀰漫性卵巢癌宿主接受化療藥物治療後的影響:著重於免疫檢查點的調控
Internal ID
NSTC114-2314-B002-070
Principal Investigator
CHIA-YING WU
Start Date
August 1, 2025
End Date
July 31, 2026
Investigators
YU-LI CHEN
Organizations
Obstetrics & Gynecology
Partner Organizations
National Science and Technology Council
Description
Keywords
IL-15
chemotherapy
immune checkpoint
tumor immunology
disseminated epithelial ovarian cancer
Description
癌症蟬聯國家十大死亡原因之首,顯示發展癌症的治療方式與提升其效果相當重要。化學治療是癌症治療過程中最常見的一種方式,透過不同施打的方式也顯示會影響病人免疫系統的調控,但詳細情況仍然不明。增強介白素15活性可以促進宿主免疫反應達成有效的抗腫瘤效果。本計畫預計利用多種施打化學治療的策略來調控病人之免疫系統,探討多種不同形式之介白素15與表現在免疫細胞的免疫檢查點之關係。此外,本計畫的目的為評估改變化療藥物施打策略並結合免疫檢查點抑制劑透過介白素15相關的調控機制以達到對荷瘤宿主最佳之腫瘤治療效果。
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