Project title
新式生物指標預測術後急性腎臟損傷
Internal ID
NSC100-2314-B002-119
Principal Investigator
Start Date
August 1, 2011
End Date
July 12, 2012
Investigators
Partner Organizations
Project Web Site
Novel Biomarker to Predict Cardiac Surgery Associated Acute Kidney Injury = 新式生物指標預測術後急性腎臟損傷
Keywords
Translational medicine
Animal models for human diseases
Functional OMICs
Description
Postoperative acute renal failure is a serious complication resulting in a prolonged stay and high mortality. Acute renal failure (ARF) develops in 5 to 30% of patients who undergo surgery, and for all causes, it is associated with mortality rates of 60–70%. Despite significant technical advances in therapeutics, the mortality and morbidity rates associated with acute kidney injury remain dismally high and have not appreciably improved during the past four decades. Hypotension related ischemic reperfusion acute renal failure, and sepsis related oxidative stress and cytokines crisis could induced acute renal failure in postoperative patients. Although the serum creatinine concentration performs fairly well for estimating kidney function in patients with stable chronic kidney disease, it performs poorly in the setting of AKI. An ideal biomarker for acute kidney injury would help clinicians and scientists diagnose the most common form of acute kidney injury in hospitalized patients, acute tubular necrosis, early and accurately and may aid to risk-stratify patients with acute kidney injury by predicting the need for renal replacement therapy, the duration of acute kidney injury, the length of stay, and mortality. In this pioneer study we will find types of biomarkers fall into (1) validation of the reported novel biomarkers in post-operative AKI, merged in the pattern of panel groups. (2) explore the novel biomarkers by proteomics using the urine before and post operation. We also focus on validation the sensitivity and specificity of our newly discovered protein (Hemojuvelin, HJV),and (3) validate the above biomarkers in H2O2 injured human proximal renal tubule cell line and ischemic reperfusion AKI mice. The effect of HJV injection to rescue AKI mice will be evaluated. These markers might extend the therapeutic window during which timely and individualized patient management might be possible.