建立免疫健全小鼠之食道鱗狀上皮細胞癌模式，以開發可改善「對抗PD-1/PD-L1之免疫檢查點阻斷治療」療效的新策略( III )=Establishing Immuno-Competent Mouse Esophageal Squamous Cell Carcinoma Models for Developing Strategies to Improve the Efficacy of Anti-Pd-1/Pd-L1 Immune Checkpoint Blockade( III )

Project title

建立免疫健全小鼠之食道鱗狀上皮細胞癌模式，以開發可改善「對抗PD-1/PD-L1之免疫檢查點阻斷治療」療效的新策略( III )

Internal ID

NSTC113-2314-B002-005

Principal Investigator

Start Date

August 1, 2024

End Date

July 31, 2025

Investigators

Organizations

Partner Organizations

National Science and Technology Museum

Keywords

esophageal squamous cell carcinoma (ESCC)

immune-competent mouse model

programmed cell death protein -1 (PD-1)

immune checkpoint blockade (ICB)

combination therapy

Description

我們預期這項研究將成功建立代表人類食道癌不同致癌過程的各種小鼠食道癌模型，並將找出關鍵的免疫逃逸或免疫抑制機制，及可提升PD-1/PD-L1抑制劑對食道癌療效的可能策略。我們相信，這些發現將為研發PD-1/PD-L1抑制劑為基礎的合併處方以治療食道癌，奠定重要的基礎。