Reconstituted Immunity against Persistent Parvovirus B19 Infection in a Patient with Acquired Immunodeficiency Syndrome after Highly Active Antiretroviral Therapy
Resource
CLINICAL INFECTIOUS DISEASES v.32 n.9 pp.1361-1365
Journal
CLINICAL INFECTIOUS DISEASES
Journal Volume
v.32
Journal Issue
n.9
Pages
1361-1365
Date Issued
2001
Date
2001
Author(s)
CHEN, MAO-YUAN
Abstract
We discovered a patient with AIDS with persistent B19 infection who had slow resolution of anemia after he commenced receiving HAART without intravenous immunoglobulin . The patient's anemia recurred when the initial course of HAART failed, but it remitted slowly after salvage therapy was instituted. However, circulating B19 was still detectable by nested polymerase chain reaction 1 year after commencement of salvage therapy. Immunoglobulin G and immunoglobulin M antibodies against B19 were not detected by means of enzyme-linked immunosorbent assay when the anemia initially resolved, but they were detected after the patient commenced receiving salvage therapy. The absence of antibody response after the initial remission of parvovirus B19 infection suggested that cellular immunity was an important component of reconstituted immune function against B19 after the patient received HAART. The humoral response that was restored later was abnormal; it had strong reactivity to nonstructural protein NS-1 and poor generation of neutralizing antibodies against linear epitopes unique to minor capsid protein VP1.
Subjects
RED-CELL APLASIA
IMMUNOGLOBULIN THERAPY
AIDS
ANTIBODIES
PROTEINS
DURATION
SDGs
Type
journal article