Placental mesenchymal stem cells boost M2 alveolar over M1 bone marrow macrophages via IL-1β in Klebsiella-mediated acute respiratory distress syndrome
Journal
Thorax
Date Issued
2023
Author(s)
Wang, Li-Tzu
Yen, B Linju
Wang, Hsiu-Huan
Chao, Ying-Yin
Lee, Wei
Huang, Li-Yueh
Chiu, Sheng-Kang
Siu, L Kristopher
Liu, Ko-Jiunn
Sytwu, Huey-Kang
Abstract
Acute respiratory distress syndrome (ARDS) is a lethal complication of severe bacterial pneumonia due to the inability to dampen overexuberant immune responses without compromising pathogen clearance. Both of these processes involve tissue-resident and bone marrow (BM)-recruited macrophage (MΦ) populations which can be polarised to have divergent functions. Surprisingly, despite the known immunomodulatory properties of mesenchymal stem cells (MSCs), simultaneous interactions with tissue-resident and recruited BMMΦ populations are largely unexplored.
Subjects
ARDS; bacterial Infection; macrophage biology; respiratory infection
SDGs
Publisher
BMJ PUBLISHING GROUP
Type
journal article