Preparation of Calebin-A Liposomes and its Antiproliferation in Human Cancer Cells
Journal
Journal of Analytical & Pharmaceutical Research
Journal Volume
5
Journal Issue
2
Date Issued
2017-06
Author(s)
Abstract
Calebin-A is a curcuminoid compound isolated from turmeric. Herein, we investigated the antiproliferative effect of calebin-A liposomes on cell growth compared with calebin-A. In this study, the calebin-A liposomes were successfully prepared by thin film-sonication method. The antiproliferative activity was evaluated in mouse neuroblastoma Neuro-2a cells and human SW480 colorectal tumor cells. Calebin-A liposomes (CAL) exhibited relatively uniform particle size distribution and perfectly stable during storage period of 3 weeks. The growth of SW480 and N2A cell could be inhibited by CAL. Liposomes could be an effective delivery system to enhance the Calebin-A bioactivity. The results have an important implication for using calebin-A liposomes for colon cancer prevention and therapeutics.
SDGs
Type
journal article