Reye's Syndrome Developing in an Infant on Treatment of Kawasaki Syndrome
Resource
JOURNAL OF PAEDIATRICS AND CHILD HEALTH v.41 n.5-6 pp.303-304
Journal
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
Journal Volume
v.41
Journal Issue
n.5-6
Pages
303-304
Date Issued
2005
Date
2005
Author(s)
WEI, CHIH-MING
CHEN, HUEY-LING
LEE, PING-ING
CHEN, CHUNG-MING
MA, JUINE-YIH
HWU, WUH-LIANG
Abstract
Aspirin is commonly used as an anti-inflammatory therapy for Kawasaki syndrome. Early initiation with high dose aspirin( 80 to>100 mg/kg per day ), followed by low-dose therapy at the afebrile stage, has been often used to reduce morbidity and mortality in coronary complications. We report a 10- month-old infant who was diagnosed with Kawasaki syndrome. Sudden onset of poor activity, poor appetite, lethargy, tachycardia, tachypnea, hepatomegaly, increased AST/ALT, coagulopathy and hyperammonemia developed 3 days after the high-dose aspirin therapy. His histopathological and ultrastructural findings from the liver biopsy were compatible with Reye's syndrome. He recovered completely, and there was no recurrence.
Subjects
Kawasaki syndrome
Reye's syndrome
aspirin
Type
journal article