Estimating genotype relative risks in case-parental control studies: A Mantel-Haenszel approach
Journal
Chinese Journal of Public Health
Journal Volume
19
Journal Issue
6
Pages
485-490
Date Issued
2000
Author(s)
Chang C.-H.
Abstract
Objectives: Epidemiologists often study the relationship between a susceptibility gene and a disease using the case-control design. Due to stratification/admixture that may exist in the study population, the conventional case-control design may lead to biased estimation of 'genotype relative risks'(GRRs). This problem can be circumvented by using the 'case-parental control design' instead. Under this design, there have been three non-iterative methods for estimating GRRs proposed in the literature. Here we propose a new non-iterative method using the Mantel-Haenszel(M-H) concept. Methods: The above four methods have similar formula apart from the weighting constants. The weighting constants used in the M-H method are 1.5. Results: Monte-Carlo simulation shows that the above four methods all produce estimates that are approximately unbiased. However, the M-H method has the smallest variance and hence is the most stable among the four methods. Conclusions: The M-H method is simple to calculate and more stable than the other three non-iterative methods for the estimation of the GRRs in the case-parental control study.
Subjects
Case-parental control study; Epidemiologic methodology; Genetic epidemiology; Genotype relative risks; Mantel-Haenszel method
SDGs
Other Subjects
article; case control study; genetic disorder; genetic risk; genetic susceptibility; genotype; human; risk factor; simulation
Type
journal article