Cyclin-Dependent Kinase 9 Inhibition as a Potential Treatment for Hepatocellular Carcinoma

Composite cyclin-dependent kinase (CDK) inhibition has shown potential as a treatment for hepatocellular carcinoma (HCC) in preclinical studies. We tested whether the specific inhibition of CDK9 was effective against HCC.

Subjects

Apoptosis; Cell line; Cyclin; Cyclin-dependent kinase 9; Hepatocellular carcinoma; Myeloid cell leukemia-1; Orthotopic model; Preclinical study; RNA polymerase; Xenograft