Inhibition of Trypanosoma cruzi and T. brucei NADH fumarate reductase by benznidazole and anthelmintic imidazole derivatives
Resource
MOLECULAR AND BIOCHEMICAL PARASITOLOGY v.82 n.1 pp.125-129
Journal
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
Journal Volume
v.82
Journal Issue
n.1
Pages
125-129
Date Issued
1996
Date
1996
Author(s)
CHIANG, SU-CHI
YU, JEN-CHIEH
LEE, SHO, TONE
Abstract
The switch of dominance from wildtype-specific to variant specific minicircles in arsenite-resistant L. major with DNA amplification resembles the pattern as those described for L. m. amazonensis. In the maxicircle, sequence rearrangements on the sequence of the genes in the coding region and the sequence changes in divegent regions of maxicircle remain be determined. This report delineate however one important question that transkinetoplastidy[8-10 ] as described in L. m. amazonensis can be found in other Leishmania species too.