Serum levels of pepsinogen I and gastrin in gastric carcinoma: The influence of Helicobacter pylori infection and tumor characteristics
Journal
Hepato-Gastroenterology
Journal Volume
40
Journal Issue
6
Pages
600-603
Date Issued
1993
Author(s)
Abstract
The influence of Helicobacter pylori infection on serum levels of pepsinogen I and gastrin in gastric carcinoma was investigated by simultaneous determination of serum pepsinogen I, gastrin, and IgG antibodies against Helicobacter pylori in 100 patients with gastric carcinoma, and in another 100 age- and sex-matched healthy controls. Serum pepsinogen I level was significantly lower in gastric carcinoma than in controls (55.5 ± 28.1 vs. 76.9 ± 25.1 ng/ml, p < 0.005), but there was no difference in serum gastrin between them (63.2 ± 30.2 vs. 57.4 ± 28.5 pg/ml, p = 0.16). Helicobacter pylori infection caused a significant increase in serum PGI level in advanced, intestinal type, and non-cardia gastric carcinoma. The serum gastrin level was affected by neither Helicobacter pylori infection nor any of the tumor characteristics. It is concluded that pepsinogen I, rather than gastrin, in the serum is greatly influenced by Helicobacter pylori infection and tumor characteristics in gastric carcinoma.
SDGs
Other Subjects
bacterium antibody; gastrin; immunoglobulin g; pepsinogen i; adult; aged; article; controlled study; enzyme blood level; female; gastrin blood level; gram negative infection; helicobacter pylori; human; major clinical study; male; priority journal; stomach carcinoma; Adult; Aged; Aged, 80 and over; Female; Gastrins; Helicobacter Infections; Helicobacter pylori; Human; Male; Middle Age; Pepsinogens; Stomach Neoplasms; Support, Non-U.S. Gov't
Type
journal article