Anti-Inflammatory Polyoxygenated Steroids from the Soft Coral Sinularia sp.
Resource
Bulletin of the Chemical Society of Japan 81 (12): 1616-1620
Journal
Bulletin of the Chemical Society of Japan
Journal Volume
81
Journal Issue
12
Pages
1616-1620
Date Issued
2008
Date
2008
Author(s)
Abstract
Four new polyhydroxylated steroids (1-4) were isolated from a Formosan soft coral Sinularia sp. The structures of these metabolites were determined on the basis of spectroscopic (IR, MS, and ID and 2D NMR) analyses. Among these metabolites, 3 and 4 are rarely found marine steroids with a C-9/C-10 double bond. Compounds 1 and 2 have shown significant inhibition of the accumulation of the pro-inflammatory COX-2 protein of LPS-stimulated RAW264.7 macrophage cells at l0μM. © 2008 The Chemical Society of Japan.
SDGs
Other Subjects
Metabolites; Nuclear magnetic resonance; Double bonds; Macrophage cells; Polyoxygenated steroids; Lipids
Type
journal article
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