Thalidomide對鼠部份肝切除後肝臟再生及血管增生相關生長因子之影響
Date Issued
2003-07-31
Date
2003-07-31
Author(s)
胡瑞恆
DOI
912314B002259
Abstract
Angiogenesis plays important roles in the cancer growth of many kinds,
including hepatocellular carcinoma (HCC). It is an important step in the
tumorogenesis and tumor metastasis. Some antibodies to the vascular growth factor
and some naturally occurring anti-angiogenesis molecules are used now in the
management of cancer treatment to those refractory cancers that are unresponsive to
traditional treatment modalities. Promising effects are reported in these kinds of
animal and clinical experiments. Thalidomide, a sedative with anti-angiogenesis
activity, which was abandoned due to its teratogenesity to fetus, is now revised bcause
of its anti-angiogenesis activity. As important as in tumorogenesis, angiogenesis is
also an important step in the regeneration of liver after partial hepatectomy. In the
treatment of HCC, thalidomide shows some promising effect in the control of tumor
growth. On the other hand, whether thalidomide will interfere with liver regeneration
after partial hepatectomy is an interesting topic to clinicians. In this experiment, we
study the effect of thalidomide on liver regeneration after hepatectomy in a rat model.
The effect of Thalidomide on the healing of surgical wound will be evaluated during
the same experiment.
SDGs
Publisher
臺北市：國立臺灣大學醫學院外科
Type
report
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