Association of HLA-DR14-DR52 with low responsiveness to hepatitis B vaccine in Chinese residents in Taiwan
Journal
Vaccine
Journal Volume
11
Journal Issue
14
Pages
1437-1440
Date Issued
1993
Author(s)
Abstract
To determine the HLA-linked immune response gene that controls low responsiveness to hepatitis B surface antigen (HBsAg), HLA typing was performed in 33 initial non-responders (male:female = 23:10, age 1.5-46 years) who had poor antibody response (anti-HBs < 10 mIU ml-1) after four doses of plasma-derived hepatitis B vaccine. Of 33 initial non-responders, 26 received two additional doses of either the same vaccine (n = 18) or recombinant hepatitis B vaccine (n = 8) and returned for anti-HBs measurement. At 1 month after the sixth dose, anti-HBs was still <10 mIU ml-1 in 20 cases and 10-20 mIU ml-1 in three cases. Analysis of HLA antigen frequencies in these 23 ultimate low responders revealed that nine (39%) were positive for DR14, a statistically significant association of low responsiveness to hepatitis B vaccine with HLA-DR14. In addition, 26% of the ultimate low-responders were positive for DQ3, a frequency significantly lower than the expected rate in the general population. Among the nine ultimate low-responders with DR14, seven were heterozygous for this allele, while the other two cases had a single isolated DR14; and all nine were in association with DR52. These results suggest that a DR14-DR52 association, probably dominantly expressed, may be involved in the low immune responsiveness to hepatitis B vaccine of the Chinese population in Taiwan. ? 1993.
SDGs
Other Subjects
hepatitis b vaccine; HLA DR antigen; article; controlled study; ethnic group; hepatitis b; hepatitis b virus; HLA typing; human; human cell; immune response; major clinical study; priority journal; taiwan; vaccination; Adolescent; Adult; Antibody Formation; Child; Child, Preschool; China; Female; Genetic Markers; Hepatitis B Surface Antigens; Hepatitis B Vaccines; HLA Antigens; HLA-DR Antigens; Human; Infant; Infant, Newborn; Male; Middle Age; Support, Non-U.S. Gov't; Taiwan; Vaccination
Type
journal article