台灣烏腳病地區居民對無機砷甲基化能力與週邊血管疾病相關性的研究
Date Issued
2005
Date
2005
Author(s)
曾慶孝
DOI
932320B002071
Abstract
This study examined the interaction between
arsenic exposure and urinary arsenic
speciation on the risk of peripheral vascular
disease (PVD) in blackfoot disease
(BFD)-hyperendemic area in Taiwan. A total
of 479 (220 men and 259 women) adults
residing in the BFD-hyperendemic area were
studied. Doppler ultrasound was used to
diagnose PVD. Arsenic exposure was
estimated by an index of cumulative arsenic
exposure (CAE). Urinary levels of total
arsenic, inorganic arsenite (As III ) and arsenate
(As V ), monomethylarsonic acid (MMA V ) and
dimethylarsinic acid (DMA V ) were
determined. Primary methylation index
[PMI=MMA V /(As III +As V )] and secondary
methylation index (SMI=DMA V /MMA V )
were calculated. The association between
PVD and urinary arsenic parameters was
evaluated with consideration of the
interaction with CAE and the confounding
effects of age, sex, body mass index, total
cholesterol, triglycerides, cigarette smoking
and alcohol consumption. Results showed
that PVD risk increased with a higher CAE
and a lower capacity to methylate arsenic to
DMA V . The multivariate-adjusted odds ratios
for CAE of 0, 0.1-15.4 and >15.4 mg/L浵汴楰汹year
were 1.00, 3.41 (0.74-15.78) and 4.62
(0.96-22.21), respectively (p<0.05, trend test);
and for PMI ≦1.77 and SMI>6.93, PMI>1.77
and SMI>6.93, PMI>1.77 and SMI ≦6.93,
and PMI ≦1.77 and SMI ≦6.93 were 1.00,
2.93 (0.90-9.52), 2.85 (1.05-7.73) and 3.60
(1.12-11.56), respectively (p<0.05, trend test).
It was concluded that individuals with a
higher arsenic exposure and a lower capacity
to methylate inorganic arsenic to DMA V have
a higher risk of developing PVD in BFD-hyperendemic area in Taiwan.
Subjects
peripheral vascular disease
environmental pollutants
arsenic methylation
urinary arsenic speciation
SDGs
Publisher
臺北市：國立臺灣大學醫學院內科
Type
report
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