Follicular variant of papillary thyroid carcinoma: Diagnostic limitations of fine needle aspiration cytology
Journal
Acta Cytologica
Journal Volume
49
Journal Issue
4
Pages
383-386
Date Issued
2005
Author(s)
Abstract
Objective: To study the diagnostic sensitivity and specificity of fine needle aspiration cytology (FNAC) of follicular variant of papillary thyroid carcinoma (FVPTC). Study Design: The study group consisted of 390 papillary thyroid carcinoma (PTC) cases diagnosed histologically with thyroidectomy specimens. The FNAC and histopathologic classification were compared in terms of the appearance of FVPTC and non-FVPTC statistically with the χ2 test. Also, several features of the cytologic smears of FVPTC were reviewed. Results: Twelve of the 390 PTC cases were classified as FVPTC histologically. Five of the 12 cases were also reported as FVPTC in the diagnosis by FNAC and the other 7 as the usual type of PTC (UTPTC). There was 1 case classified as UVPTC histologically but FVPTC cytologically. If we use histologic diagnosis as the gold standard, the sensitivity and specificity of FNAC diagnosis of FVPTC were 42% and 83%, respectively. Conclusion: FNAC may be a good tool for diagnosing PTC, but it is-unreliable to differentiate between FVPTC and UTPTC. ? The International Academy of Cytology.
SDGs
Other Subjects
adult; article; aspiration biopsy; aspiration cytology; cancer diagnosis; clinical article; diagnostic test; diagnostic value; female; histopathology; human; human tissue; male; priority journal; sensitivity and specificity; thyroid papillary carcinoma; thyroidectomy; tumor differentiation
Publisher
S. Karger AG
Type
journal article