Metformin is associated with decreased skin cancer risk in Taiwanese patients with type 2 diabetes
Journal
Journal of the American Academy of Dermatology
Journal Volume
78
Journal Issue
4
Pages
694-700
Date Issued
2018
Author(s)
Abstract
Background: Metformin, an antidiabetic drug, is associated with decreased cancer risk, but its effect on skin cancer is unknown. Objective: To evaluate skin cancer risk associated with metformin use. Methods: In total, 16,237 matched pairs of ever and never metformin users with new-onset type 2 diabetes diagnosed during 1999-2005 were retrospectively enrolled and followed until December 31, 2011, using Taiwan's National Health Insurance database. Hazard ratios (HRs) were estimated using Cox regression weighted for propensity scores. Results: Skin cancer incidence was 45.59 and 83.90 per 100,000 person-years among ever and never users, respectively (HR 0.540, 95% confidence interval [CI] 0.357-0.819). Among ever users, the HRs (95% CIs) for the first (<21.00 months), second (21.00-45.83 months), and third (>45.83 months) cumulative duration tertiles were 0.817 (0.448-1.489), 0.844 (0.504-1.412), and 0.114 (0.036-0.364), respectively, and the HRs (95% CIs) for the first, second, and third cumulative dose tertiles were 1.006 (0.579-1.748), 0.578 (0.317-1.051), and 0.229 (0.099-0.530), respectively. HRs (95% CIs) were 0.523 (0.175-1.562) for melanoma and 0.496 (0.319-0.772) for nonmelanoma skin cancer. Limitations: Few patients had skin cancer and information on ultraviolet light exposure and tumor histopathology was lacking. Conclusion: Metformin use is associated with a decreased skin cancer risk. ? 2017 American Academy of Dermatology, Inc.
Subjects
diabetes mellitus; metformin; skin cancer; Taiwan
SDGs
Other Subjects
insulin; meglitinide; metformin; sulfonylurea; antidiabetic agent; metformin; adult; Article; cancer risk; disease duration; drug screening; female; health care system; human; ICD-9-CM; incidence; major clinical study; male; melanoma; national health insurance; non insulin dependent diabetes mellitus; non melanoma skin cancer; priority journal; reimbursement; retrospective study; skin cancer; Taiwan; aged; middle aged; non insulin dependent diabetes mellitus; risk assessment; skin tumor; Adult; Aged; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Retrospective Studies; Risk Assessment; Skin Neoplasms; Taiwan
Publisher
Mosby Inc.
Type
journal article