The immunomodulatory effects of lactic acid bacteria for improving immune functions and benefits
Journal
Applied Microbiology and Biotechnology
Journal Volume
96
Journal Issue
4
Pages
853-862
Date Issued
2012
Author(s)
Abstract
Probiotics have a number of beneficial health effects in humans and animals, such as reducing lactose intolerance symptoms and enhancing the bioavailability of nutrients. Probiotics help regulate intestinal microflora and immunomodulatory properties. Probiotics also decrease the prevalence of allergies in susceptible individuals, inhibit the inflammatory responses in the gut, and have antagonistic effects against intestinal and food-borne pathogens. Bacteria typically colonize the intestinal tract first and then reinforce the host defense systems by inducing generalized mucosal immune responses, including modulation of DC/NK interaction, a balanced T-helper cell response, self-limited inflammatory response, and the secretion of polymeric IgA. A lot of reports showed that lactic acid bacteria (LAB) as Lactobacillus and Bifidobacterium and their fermented products are effective at enhancing innate and adaptive immunity, prevent gastric mucosal lesion development, alleviate allergies, and put up defense against intestinal pathogen infection. In this review paper, we compared the influence of immunomodulatory effects on the function and efficacy of lactobacillus products with different strains. We also discuss the beneficial effects of several LAB strain and its derivative products for human immunity and related diseases. ? Springer-Verlag Berlin Heidelberg 2012.
Subjects
Allergy; Escherichia coli O157:H7; Innateimmuneresponse .Mucosalimmunity; Lactobacillus paracasei subsp. paracasei NTU 101
SDGs
Other Subjects
Adaptive immunity; Antagonistic effects; Beneficial effects; Bifidobacterium; Cell response; Escherichia coli O157:H7; Food-borne pathogens; Health effects; Host defense; Immune function; Immunomodulatory effects; Inflammatory response; Innateimmuneresponse .Mucosalimmunity; Intestinal tract; Lactic acid bacteria; Lactobacillus paracasei subsp. paracasei NTU 101; Microflora; Mucosal immune response; Pathogen infection; Probiotics; Bacilli; Biochemistry; Escherichia coli; Lactic acid; Pathogens; Strain; Sugars; Allergies; gamma interferon; interleukin 12; lactic acid; major histocompatibility antigen class 2; probiotic agent; toll like receptor 4; toll like receptor 5; tumor necrosis factor alpha; allergy; bacteriology; bacterium; bioavailability; colonization; fermentation; health impact; immune response; immune system; immunity; immunoassay; lesion; mucus; probiotics; public health; symptom; adaptive immunity; allergy; bacterial strain; cytokine production; dendritic cell; drug efficacy; enteritis; human; immunity; immunomodulation; innate immunity; intestine mucosa; lactic acid bacterium; Lactobacillus paracasei; nonhuman; review; Animals; Bifidobacterium; Gastrointestinal Diseases; Gastrointestinal Tract; Humans; Immunologic Factors; Lactobacillus; Probiotics; Animalia; Bifidobacterium; Escherichia coli; Lactobacillus; Lactobacillus paracasei subsp. paracasei
Type
journal article