A novel mucosal bivalent vaccine of EV-A71/EV-D68 adjuvanted with polysaccharides from Ganoderma lucidum protects mice against EV-A71 and EV-D68 lethal challenge
Journal
Journal of biomedical science
Journal Volume
30
Journal Issue
1
Date Issued
2023-12-18
Author(s)
Lin, Yu-Li
Cheng, Pei-Yun
Chin, Chiao-Li
Chuang, Kuan-Ting
Chang, Ning
Pan, Chun-Kei
Lin, Cheng-Sheng
Pan, Siao-Cian
Abstract
Human enteroviruses A71 (EV-A71) and D68 (EV-D68) are the suspected causative agents of hand-foot-and-mouth disease, aseptic meningitis, encephalitis, acute flaccid myelitis, and acute flaccid paralysis in children. Until now, no cure nor mucosal vaccine existed for EV-A71 and EV-D68. Novel mucosal bivalent vaccines are highly important for preventing EV-A71 and EV-D68 infections.
Subjects
Acute flaccid myelitis; Acute flaccid paralysis; Adjuvant; Enterovirus A71; Enterovirus D68; Ganoderma lucidum polysaccharide; Intranasal; Mucosal vaccine
SDGs
Type
journal article