Emerging importance of infections due to zygomycetes in organ transplant recipients
Journal
International Journal of Antimicrobial Agents
Journal Volume
32
Journal Issue
SUPPL. 2
Pages
S115-S118
Date Issued
2008
Author(s)
Singh N.
Abstract
Zygomycetes are being increasingly recognised as important opportunistic pathogens in immunocompromised hosts, including transplant recipients. Conflicting data exist with regard to the contribution of newer antifungal agents such as voriconazole as risk factors for zygomycosis. Although survival rates have improved, outcomes in patients with zygomycosis remain suboptimal. Combination antifungal therapies as well as unique interactions of calcineurin inhibitor immunosuppressive agents with antifungals have potentially relevant implications for optimising outcomes in zygomycosis. ? 2008 Elsevier BV.
SDGs
Other Subjects
amphotericin B deoxycholate; amphotericin B lipid complex; anidulafungin; antifungal agent; calcineurin inhibitor; caspofungin; deferasirox; deferiprone; echinocandin; fluconazole; iron; itraconazole; ketoconazole; micafungin; posaconazole; voriconazole; article; clinical trial; cryptococcosis; disease predisposition; drug potentiation; fungus growth; graft recipient; hematopoietic stem cell transplantation; human; iron chelation; mortality; mucormycosis; nonhuman; outcome assessment; priority journal; risk factor; survival rate; treatment outcome; Zygomycetes; Antifungal Agents; Drug Interactions; Humans; Immunocompromised Host; Immunosuppressive Agents; Transplants; Zygomycosis
Type
journal article