Gut microbiota dysbiosis-related susceptibility to nontuberculous mycobacterial lung disease
Journal
Gut microbes
Journal Volume
16
Journal Issue
1
Start Page
2361490
ISSN
1949-0984
Date Issued
2024
Author(s)
Lin, Tzu-Lung
Kuo, Yen-Liang
Lai, Juo-Hsin
Lu, Chia-Chen
Hsu, Chi-Yu
Wu, Lawrence Shih-Hsin
Wu, Ting-Shu
Shu, Jwu-Ching
Abstract
The role of gut microbiota in host defense against nontuberculous mycobacterial lung disease (NTM-LD) was poorly understood. Here, we showed significant gut microbiota dysbiosis in patients with NTM-LD. Reduced abundance of was significantly associated with NTM-LD and its disease severity. Compromised TLR2 activation activity in feces and plasma in the NTM-LD patients was highlighted. In the antibiotics-treated mice as a study model, gut microbiota dysbiosis with reduction of TLR2 activation activity in feces, sera, and lung tissue occurred. Transcriptomic analysis demonstrated immunocompromised in lung which were closely associated with increased NTM-LD susceptibility. Oral administration of or its capsular polysaccharides enhanced TLR2 signaling, restored immune response, and ameliorated NTM-LD susceptibility. Our data highlighted the association of gut microbiota dysbiosis, systematically compromised immunity and NTM-LD development. TLR2 activation by or its capsular polysaccharides might help prevent NTM-LD.
Subjects
Gut microbiota dysbiosis
TLR2 activation
capsular polysaccharide
nontuberculous mycobacterial lung disease
prevotella copri
SDGs
Type
journal article