Synthesis and characterization of pH-triggered doxorubicin-conjugated polydopamine-coated cobalt ferrite nanoparticles for in-vitro/in-vivo studies in liver cancer therapy
Journal
Journal of Industrial and Engineering Chemistry
Journal Volume
129
Pages
499-510
Date Issued
2024-01-25
Author(s)
DOI
10.1016/j.jiec.2023.09.009
Abstract
Polydopamine-coated cobalt ferrite nanoparticles (PDA-coated CF-NPs) were synthesized and characterized for their potential in drug delivery evaluation. Small-angle X-ray scattering (SAXS) showed post-coating spherical shape of magnetic PDA NPs. The scattering intensity at zero angle (I(0)) of PDA-coated CF (0.01) had higher scattering intensity than CF-NPs (0.49 × 10-3). PDA increased the flexibility degree of unfolding on Kratky plot shifting from 1.05 to 1.87 at same qRg values. The pair-distance distribution function (P(r)) of PDA-coated CF-NPs indicated a more homogeneous and compact scattering structure. GNOM indicated larger size for CF, while PDA-coated CF (a narrower and taller peak) displayed a more compact and uniform scattering profile. PDA reduced crystallinity size to 2.51 nm with amorphous peaks at 38.12°, 44.28°, and 64.43° degree and infrared spectrum confirmed PDA incorporation onto CF-NPs. PDA-coated CF had 1.5-fold larger pore size and enhanced surface area. CF and PDA-coated CF exhibited “S” shape behavior in Langevin function without hysteresis. The kinetic models suggested Fickian diffusion and sustainable release for the erosion-dominated release of the PDA-coated CF. In vitro, doxorubicin (DOX)-carried PDA-coated CF (D-P@CF) showed low toxicity to HepG2 cells; in vivo, liver tumor inhibition indicated medication delivery potential for cancer treatment.
Subjects
Polydopamine-coated cobalt ferrite
Drug delivery
Liver cancer
pH sensitivity
Antitumor
SDGs
Type
journal article