腫瘤壞死因子變異型與感染症嚴重程度之相關性
Date Issued
2002
Date
2002
Author(s)
李秉穎
DOI
902314B002159
Abstract
Susceptibility of human to infections may be related to various genes. It is
known that tumor necrosis factor (TNF) is an important cytokine in the
inflammatory process, and it is also related to the pathogenesis of sepsis syndrome.
There have been several studies indicating the correlation between TNF gene and
various diseases. A polymorphism located 308 base pairs upstream from the
transcriptional start of the TNF-á gene has been identified that is the result of a
guanine (wild-type, TNF1) to adenine (TNF2) substitution. Although the
mechanism is unclear, the TNF2 allele appears to increase constitutive and inducible
levels of TNF-á, and has been associated with both increased susceptibility to, and
severity of, a number of infectious diseases, including sepsis and asthma. The
present study is aimed to delineate the association of TNF-á gene polymorphism
and sepsis, asthma, bronchiolitis, severe pneumonia.
Subjects
Tumor necrosis factor
polymorphism
sepsis
brochiolitis
SDGs
Publisher
臺北市：國立臺灣大學醫學院小兒科
Type
report
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