Image-guided intensity modulated radiotherapy with helical tomotherapy for postoperative treatment of high-risk oral cavity cancer
Journal
BMC Cancer
Journal Volume
11
Pages
37
Date Issued
2011
Author(s)
Hsieh C.-H.
Kuo Y.-S.
Liao L.-J.
Hu K.-Y.
Lin S.-C.
Wu L.-J.
Lin Y.-C.
Chen Y.
Hsieh Y.-P.
Lin S.L.
Chen C.-Y.
Chen C.-A.
Shueng P.-W.
Abstract
Background: The aim of this study was to assess the treatment results and toxicity profiles of helical tomotherapy (HT) for postoperative high-risk oral cavity cancer.Methods: From December 6, 2006 through October 9, 2009, 19 postoperative high-risk oral cavity cancer patients were enrolled. All of the patients received HT with (84%) or without (16%) chemotherapy.Results: The median follow-up time was 17 months. The 2-year overall survival, disease-free survival, locoregional control, and distant metastasis-free rates were 94%, 84%, 92%, and 94%, respectively. The package of overall treatment time > 13 wk, the interval between surgery and radiation ? 6 wk, and the overall treatment time of radiation ? 7 wk was 21%, 84%, and 79%, respectively. The percentage of grade 3 mucositis, dermatitis, and leucopenia was 42%, 5% and 5%, respectively.Conclusions: HT achieved encouraging clinical outcomes for postoperative high-risk oral cavity cancer patients with high compliance. A long-term follow-up study is needed to confirm these preliminary findings. ? 2011 Hsieh et al; licensee BioMed Central Ltd.
SDGs
Other Subjects
cisplatin; fluorouracil; folinic acid; antineoplastic agent; adult; aged; anemia; article; cancer control; cancer survival; chemoradiotherapy; clinical article; controlled study; dermatitis; disease free survival; distant metastasis; female; human; intensity modulated radiation therapy; leukopenia; male; mouth cancer; mucosa inflammation; oral surgery; overall survival; patient compliance; postoperative care; retrospective study; thrombocytopenia; tomotherapy; treatment outcome; weight reduction; xerostomia; clinical trial; drug effect; intensity modulated radiation therapy; leukopenia; methodology; middle aged; mouth; mouth tumor; mucosa inflammation; multimodality cancer therapy; postoperative care; radiation dermatitis; radiation dose; radiation exposure; risk factor; spiral computer assisted tomography; Adult; Aged; Antineoplastic Agents; Combined Modality Therapy; Disease-Free Survival; Female; Humans; Leukopenia; Male; Middle Aged; Mouth; Mouth Neoplasms; Mucositis; Postoperative Care; Radiodermatitis; Radiotherapy Dosage; Radiotherapy, Intensity-Modulated; Risk Factors; Tomography, Spiral Computed; Treatment Outcome; Young Adult
Type
journal article