CONSISTENCY OF GENETIC INHERITANCE MODE AND HERITABILITY PATTERNS OF TRIGLYCERIDE VS. HIGH DENSITY LIPOPROTEIN CHOLESTEROL RATIO IN TWO TAIWANESE FAMILY SAMPLES
Resource
BMC GENETICS v.4 n.1 pp.7
Journal
BMC GENETICS
Journal Volume
v.4
Journal Issue
n.1
Pages
p-7
Date Issued
2003
Date
2003
Author(s)
CHIEN, KUO-LIONG
Abstract
Background: Triglyceride/HDL cholesterol ratio (TG/HDL-C)is considered as a risk factor for cardiovascular events. Genetic components were important in controlling the variation in western countries. But the mode of inheritance and family aggregation patterns were still unknown among Asian-Pacific countries. This study, based on families recruited from community and hospital, is aimed to investigate the mode of inheritance, heritability and shared environmental factors in controlling TG/HDL-C. Results: Two populations, one from community-based families (n = 988, 894 parent-offspring and 453 sibling pairs) and the other from hospital-based families ( n = 1313, 76 parent-offspring and 52 sibling pairs) were sampled. The population in hospital-based families had higher mean age values than community-based families (54.7 vs. 34.0). Logarithmic transformed TG/HDL-C values, after adjusted by age, gender and body mass index, were for genetic analyses. Significant parent-offspring and sibling correlations were also found in both samples. The parent-offspring correlation coefficient was higher in the hospital-based families than in the community-based families. Genetic heritability was higher in community-based families (0.338 +/- 0.114, p = 0.002), but the common shared environmental factor was higher in hospital-based families (0.203 +/- 0.042, p < 0.001). Commingling analyses showed that more than one-component distribution models were the best-fit models to explain the variance in both populations. Complex segregation analysis by regressive models revealed that in both samples the best- fit model of TG/HDL-C was the model of environmental effects plus familial correlation, in which significant parent- offspring and sibling correlations were demonstrated . Models of major gene effects were rejected in both samples . Conclusion: Variations of TG/HDL-C in the normal ranges were likely to be influenced by multiple factors, including environmental and genetic components. Higher genetic factors were proved in younger community-based families than in older hospital-based families.
Subjects
APOLIPOPROTEIN-A-I
CORONARY HEART-DISEASE
PLASMA HDL- CHOLESTEROL
CLINICS PROGRAM FAMILY
SEGREGATION ANALYSIS
QUANTITATIVE-TRAIT
Type
journal article
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