(Invited) Nanowire Field-Effect Transistor-Based Biosensors as a Tool for Life Science
Journal
ECS Transactions
Journal Volume
64
Pages
23-32
Date Issued
2014
Author(s)
Abstract
Electrical biosensors based on silicon nanowire field-effect transistors (SiNW-FETs) have attracted enormous interest in the biosensing field. SiNW-FETs have proven to be significant and efficient in detecting diverse biomolecular species with the advantages of high probing sensitivity, target selectivity, real-time recording, and label-free detection. In recent years, significant advances in biosensors have been achieved, particularly for cellular investigation and biomedical diagnosis. In this paper, we will report on the recent achievements with SiNW-FET biosensors for the fast screening of protein-protein interaction and sensitive detection of neurotransmitters release from live cells. Despite these remarkable achievements, certain improvements remain necessary in the device performance and clinical applications of FET-based biosensors; thus, several prospects about the future development of nanowire transistor-based instruments for biosensing employments are discussed at the end of this paper.
Type
journal article