Differentiation of schizophrenia patients from healthy subjects by mismatch negativity and neuropsychological tests
Journal
PLoS ONE
Journal Volume
7
Journal Issue
4
Pages
e34454
Date Issued
2012
Author(s)
Jaw, F.-S.
Shan, J.-C.
Abstract
Background: Schizophrenia is a heterogeneous disorder with diverse presentations. The current and the proposed DSM-V diagnostic system remains phenomenologically based, despite the fact that several neurobiological and neuropsychological markers have been identified. A multivariate approach has better diagnostic utility than a single marker method. In this study, the mismatch negativity (MMN) deficit of schizophrenia was first replicated in a Han Chinese population, and then the MMN was combined with several neuropsychological measurements to differentiate schizophrenia patients from healthy subjects. Methodology/Principal Findings: 120 schizophrenia patients and 76 healthy controls were recruited. Each subject received examinations for duration MMN, Continuous Performance Test, Wisconsin Card Sorting Test, and Wechsler Adult Intelligence Scale Third Edition (WAIS-III). The MMN was compared between cases and controls, and important covariates were investigated. Schizophrenia patients had significantly reduced MMN amplitudes, and MMN decreased with increasing age in both patient and control groups. None of the neuropsychological indices correlated with MMN. Predictive multivariate logistic regression models using the MMN and neuropsychological measurements as predictors were developed. Four predictors, including MMN at electrode FCz and three scores from the WAIS-III (Arithmetic, Block Design, and Performance IQ) were retained in the final predictive model. The model performed well in differentiating patients from healthy subjects (percentage of concordant pairs: 90.5%). Conclusions/Significance: MMN deficits were found in Han Chinese schizophrenia patients. The multivariate approach combining biomarkers from different modalities such as electrophysiology and neuropsychology had a better diagnostic utility. ? 2012 Lin et al.
SDGs
Other Subjects
chlorpromazine; clozapine; neuroleptic agent; biological marker; adult; age distribution; article; clinical examination; Continuous Performance Test; controlled study; disease marker; electroencephalogram; ethnic group; female; human; major clinical study; male; mismatch negativity; neuropsychological test; patient selection; population research; psychologic test; schizophrenia; Wechler Adult Intelligence Scale; Wisconsin Card Sorting Test; adolescent; aged; case control study; comparative study; contingent negative variation; electroencephalography; middle aged; predictive value; psychological rating scale; psychology; schizophrenia; Adolescent; Adult; Aged; Biological Markers; Case-Control Studies; Contingent Negative Variation; Electroencephalography; Female; Humans; Male; Middle Aged; Neuropsychological Tests; Predictive Value of Tests; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology; Young Adult
Type
journal article