A straightforward strategy to spatially organize repulsive and attractive cues on Zwitterionic PEDOTs
Journal
Colloids and Interface Science Communications
Journal Volume
50
Date Issued
2022-09-01
Author(s)
Zhu, Yicheng
Lin, Hsing An
Zhang, Shouyan
Pan, Qichao
Qian, Sihao
Zhang, Shuhua
Zhang, Yaqiong
Yu, Hsiao Hua
Zhu, Bo
Abstract
Solving the conflict between the low impedance and biofunctionalization for the patterned conducting polymer biointerface/devices remains a challenge. Moreover, with our limited knowledge, the efforts to fabricate a patterned conducting polymer biointerface free from nonspecific protein/cell interaction are also missing. Herein, we developed a strategy to spatially organize cell-repulsive and attractive cues on an all-conducting-polymer biointerface by using two zwitterionic poly(3,4-ethylenedioxythiophene) (PEDOT) copolymers with opposite cell affinities. This dual-biofunction pattern of the PEDOT platform, mimicking the brain microenvironment for neural circuit assembly, organizes the cell-repulsive and specific cell-attractive cues spatially to regulate the cell attachment and differentiation. This platform also demonstrated a striking integration of low impedance and nonspecific protein/cell-binding resistance. We envision this approach, utilizing the diverse zwitterionic PEDOTs, would be attractive for bioelectronic applications, where a precise collection/delivery of electrical signals is necessary.
Subjects
Antifouling | Cell patterning | Phosphorylcholine | Poly(3,4-ethylenedioxythiophene) | Zwitterion
Publisher
ELSEVIER
Type
journal article