Modification of Mesoporous Silica Nanoparticles for Biomedical Applications
Date Issued
2011
Date
2011
Author(s)
Su, Yi-Fan
Abstract
Mesoporous silica nanoparticles (MSNs) are emerging as promising candidates in using these materials for biomedical applications because of the unique characteristics, including high surface area, uniform pore size, easy modification and great biocompatibility. In first part, we have successfully developed two kinds of materials base on mesoporous silica nanoparticles (MSN) for biomedical applications. The first part shows the synthesis and characterization of a multifunctional nanomaterial, Gd(OH)3-FITC@MSN, possessing magnetic, fluorescent and porous properties. Its utility for both magnetic resonance and optical imaging was clearly demonstrated in vitro. The result shows Gd(OH)3-FITC@MSN performed well for cellular magnetic resonance imaging (MRI) even at high magnetic field (7T), indicating it could be a promising T1 or T2 contrast agent.
The second part presents a systematic study of 50 nm MSN modified with PEG of different molecular weights and surface chain density. The results show that, as the surface of MSN mostly covered by PEG with molecular weight of 30 kDa, the PEGylated MSN could stably suspend in cell-culture medium and physiology environments without agglomeration and obvious size changes even incubated for two weeks. Besides, MSNs conjugated with PEG chains effectively reduce non-specific uptake of RAW 264.7 macrophage cells indicating these particles could escape from the innate immune system which is critical for efficient target-specific delivery.
Subjects
Mesoporous silica nanoparticles
multifunctional nanoaprobes
MRI
contrast agents
PEGylation
phagocytosis
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