Glucose Sensing on an Optofluidic Silicon Chip
Date Issued
2012
Date
2012
Author(s)
Lee, Agnes
Abstract
This thesis presents a glucose sensing method on a miniature optofluidic silicon chip based on the idea of diffusion. Two cases of diffusion, one without external flow and one with an external flow rate of 10 ul/min are analyzed both theoretically by COMSOL simulation and experimentally. The experiment utilized an silicon on insulator (SOI) chip containing 4 sets of microring
resonators. The SOI chip was integrated with designed microfluidic channels, including a flow channel and a diffusion channel. A flow with glucose concentration was imported and exported through the flow channel. The
diffusion channel was designed with three impermeable boundaries and one open boundary connected to the flow channel. In this case the glucose particles could penetrate through the diffusion channel only through diffusion. The microring resonators lied within the diffusion channel and detected the diffusion effect of the system. In the case without flow, the diffusion coefficient extracted from the experimental result is 8.8*10^(-10) m^2/s, which is
close to the literature value 9.4*10^(-10) m^2/s. The diffusion speed obtained in the case with flow is higher than that in the theoretical simulation because of the driven convection in the lid-driven cavity.
resonators. The SOI chip was integrated with designed microfluidic channels, including a flow channel and a diffusion channel. A flow with glucose concentration was imported and exported through the flow channel. The
diffusion channel was designed with three impermeable boundaries and one open boundary connected to the flow channel. In this case the glucose particles could penetrate through the diffusion channel only through diffusion. The microring resonators lied within the diffusion channel and detected the diffusion effect of the system. In the case without flow, the diffusion coefficient extracted from the experimental result is 8.8*10^(-10) m^2/s, which is
close to the literature value 9.4*10^(-10) m^2/s. The diffusion speed obtained in the case with flow is higher than that in the theoretical simulation because of the driven convection in the lid-driven cavity.
Subjects
Glucose sensing, Diffusion, Microring resonator, Microfluidics, SOI
Type
thesis
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