The expression of mouse T-cell receptor TCRDV genes in BALB/c spleen
Journal
Immunogenetics
Journal Volume
40
Journal Issue
4
Pages
271 - 279
Date Issued
1994
Author(s)
Abstract
The rearrangement and expression of six different mouse T-cell receptor TCRDV (Vδ) gene subfamilies have been studied in BALB/c mouse spleen. The results show that all the TCRDV gene segments studied can be rearranged and expressed with both the TCRA (α) and the TCRD (δ) chain. The apparently restricted and separated V gene repertoire for the TCRD and TCRAT-cell receptor may result from thymus and peripheral selection rather than from selective rearrangement in the DNA level. Several J gene segment show how much higher concentration in spleen with TCRDV gene segments, however, these J gen segments do not tend to be located at either end of the J gene cluster. © 1994 Springer-Verlag.
Type
journal article