A universal strategy for the fabrication of single-photon and multiphoton NIR nanoparticles by loading organic dyes into water-soluble polymer nanosponges
Journal
Journal of nanobiotechnology
Journal Volume
20
Journal Issue
1
Date Issued
2022-07-06
Author(s)
Yang, Li-Xing
Liu, Yu-Cheng
Cho, Chang-Hui
Chen, Yi-Rou
Yang, Chan-Shan
Lu, Yin-Lin
Zhang, Zhiming
Tsai, Yi-Tseng
Chin, Yu-Cheng
Pan, Hsiu-Min
Jiang, Wei-Rou
Chia, Zi-Chun
Huang, Wei-Shiang
Chiu, Yu-Lin
Sun, Chun-Kai
Huang, Yu-Ting
Chen, Li-Ming
Huang, Han-Min
Chen, Chih-Hsin
Chang, Yuan Jay
Huang, Chih-Chia
Liu, Tzu-Ming
Abstract
The development of optical organic nanoparticles (NPs) is desirable and widely studied. However, most organic dyes are water-insoluble such that the derivatization and modification of these dyes are difficult. Herein, we demonstrated a simple platform for the fabrication of organic NPs designed with emissive properties by loading ten different organic dyes (molar masses of 479.1-1081.7 g/mol) into water-soluble polymer nanosponges composed of poly(styrene-alt-maleic acid) (PSMA). The result showed a substantial improvement over the loading of commercial dyes (3.7-50% loading) while preventing their spontaneous aggregation in aqueous solutions. This packaging strategy includes our newly synthesized organic dyes (> 85% loading) designed for OPVs (242), DSSCs (YI-1, YI-3, YI-8), and OLEDs (ADF-1-3, and DTDPTID) applications. These low-cytotoxicity organic NPs exhibited tunable fluorescence from visible to near-infrared (NIR) emission for cellular imaging and biological tracking in vivo. Moreover, PSMA NPs loaded with designed NIR-dyes were fabricated, and photodynamic therapy with these dye-loaded PSMA NPs for the photolysis of cancer cells was achieved when coupled with 808 nm laser excitation. Indeed, our work demonstrates a facile approach for increasing the biocompatibility and stability of organic dyes by loading them into water-soluble polymer-based carriers, providing a new perspective of organic optoelectronic materials in biomedical theranostic applications.
Subjects
Fluorescence imaging; Multiphoton microscopy; Near-infrared red; Optoelectronic material; Photodynamic therapy; Polymer; Theranostic
Publisher
BMC
Type
journal article