Design and Synthesis of an Activity Probe Library for Glycosidases
Date Issued
2006
Date
2006
Author(s)
Lai, Sin-Yi
DOI
zh-TW
Abstract
Glycosidases catalyze the hydrolysis of glycosidic linkages in aryl and alkyl glycosides, and occur widely in animals, fungi, plants, and bacteria. These enzymes played crucial roles in numerous biological process as such as cell to cell recognition and interaction, immune response, viral and bacterial infections, and so forth. Dysfunction of their activities often leads to disease conditions.
Activity probes can be used to label related enzymes. And the results could potentially be applied to drug development. The concept of activity probes is based on suicide inhibitors of enzymes. A complete activity probe contains four structural units: (1) recognition head; (2) latent trapping device; (3) linker; (4) reporter group. In this thesis, we synthesized a series of activity probes for α-/β-glucosidase, α-/β-galactosidase, α-fucosidase, α-mannosidase and α-xylosidase.
Subjects
醣苷
水解酵素
Glycosidases
Activity Probe
SDGs
Type
thesis
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