行政院國家科學委員會專題研究計畫成果報告:綠膿桿菌外毒素A誘發大鼠腹腔巨噬細胞質內顆粒組成成份分析及其產生機制的探討
Date Issued
2003
Date
2003
Author(s)
DOI
912313B002377
Abstract
Pseudomonas aeruginosa is a common
opportunistic pathogen. Exotoxin A (ETA) is the
major determining factor among all of the
substances secreted by P. aeruginosa associated
with its virulence. It inhibits mammalian cell
protein synthesis and can also influence the host
immune function. The LD50 of ETA in mice
following intraperitoneal injection is
approximately 0.2 µg. Macrophages are essential
for host defense and immune regulation.
However, information regarding the effects of
ETA on macrophages is rather limited. Our
macrophages play an important role in both
inflammation and immune regulation, it is
reasonable to speculate that these ETA-induced
effects on macrophages may certainly interfere
with the normal operation of the host defense
system.
Subjects
Pseudomonas aeruginosa
exotoxin
A
A
cytoplasmic granule
cytokine
peritoneal
macrophage
macrophage
rat
Publisher
臺北市：國立臺灣大學獸醫學系暨研究所
Type
report
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