Significant associations of prostate-specific antigen nadir and time to prostate-specific antigen nadir with survival in prostate cancer patients treated with androgen-deprivation therapy
Journal
Aging Male
Journal Volume
15
Journal Issue
1
Pages
34-41
Date Issued
2012
Author(s)
Huang S.-P.
Bao B.-Y.
Wu M.-T.
Choueiri T.K.
Goggins W.B.
Liu C.-C.
Yu C.-C.
Wu T.T.
Huang C.-N.
Huang C.-H.
Wu W.-J.
Abstract
Objective.The influence of prostate-specific antigen (PSA) kinetics on the outcome of metastatic prostate cancer (PCa) after androgen-deprivation therapy (ADT) remains poorly characterised. We evaluated the prognostic significance of PSA nadir and time to PSA nadir as well as their interactive effect on prostate cancer-specific mortality (PCSM) and all-cause mortality (ACM) after ADT. Methods.A total of 650 men with advanced or metastatic PCa treated with ADT were studied. The prognostic significance of PSA nadir and time to PSA nadir on PCSM and ACM were analysed using KaplanMeier analysis and the Cox regression model. Results.On multivariate analysis, clinical M1 stage, Gleason Score 810, PSA nadir ? 0.2 ng/ml and time to PSA nadir < 10 months were independent predictors of PCSM and ACM. The combined analysis showed that patient with higher PSA nadir and shorter time to PSA nadir had significantly higher risk of PCSM and ACM compared to those with lower PSA nadir and longer time to PSA nadir (hazard ratios=6.30 and 4.79, respectively, all P < 0.001). Conclusions.Our results suggest that higher PSA nadir level and faster time to reach PSA nadir after ADT were associated with shorter survival for PCa. ? 2012 Informa UK, Ltd.
SDGs
Other Subjects
prostate specific antigen; prostate specific antigen nadir; unclassified drug; adult; aged; androgen deprivation therapy; article; cancer mortality; cancer staging; cancer survival; Gleason score; human; major clinical study; male; metastasis; overall survival; priority journal; prostate cancer; Adult; Aged; Aged, 80 and over; Androgen Antagonists; Disease Progression; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Neoplasm Grading; Prostate-Specific Antigen; Prostatic Neoplasms
Type
journal article