KRAS and KIT gatekeeper mutations confer polyclonal primary imatinib resistance in GI stromal tumors: Relevance of concomitant phosphatidylinositol 3-kinase/AKT dysregulation
Journal
Journal of Clinical Oncology
Journal Volume
33
Journal Issue
22
Pages
e93-e96
Date Issued
2015
Author(s)
Serrano C.
Wang Y.
Mariño-Enríquez A.
Ravegnini G.
Morgan J.A.
Bertagnolli M.M.
Beadling C.
Demetri G.D.
Corless C.L.
Heinrich M.C.
Fletcher J.A.
Other Subjects
CD34 antigen; imatinib; phosphatidylinositol 3 kinase; phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase; protein kinase B; antineoplastic agent; arginine; benzamide derivative; glycine; imatinib; isoleucine; KRAS protein, human; MTOR protein, human; oncoprotein; phosphatidylinositol 3 kinase; piperazine derivative; protein kinase B; protein kinase inhibitor; pyrimidine derivative; Ras protein; stem cell factor receptor; target of rapamycin kinase; threonine; abdominal radiography; adult; Article; cancer growth; cancer resistance; case report; computer assisted tomography; drug megadose; endoscopic biopsy; enzyme activity; exon; fatigue; follow up; gastrointestinal stromal tumor; gene mutation; hematocrit; human; human tissue; immunoblotting; liver metastasis; male; middle aged; missense mutation; nausea; oncogene c kit; oncogene K ras; postoperative period; priority journal; protein expression; shoulder pain; thrombocyte count; treatment duration; carcinoma; DNA sequence; drug resistance; Gastrointestinal Stromal Tumors; genetics; metabolism; mutation; signal transduction; Stomach Neoplasms; time; Antineoplastic Agents; Arginine; Benzamides; Carcinoma; Drug Resistance, Neoplasm; Gastrointestinal Stromal Tumors; Glycine; Humans; Imatinib Mesylate; Isoleucine; Male; Middle Aged; Mutation; Phosphatidylinositol 3-Kinase; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-kit; Pyrimidines; ras Proteins; Sequence Analysis, DNA; Signal Transduction; Stomach Neoplasms; Threonine; Time Factors; TOR Serine-Threonine Kinases
Publisher
American Society of Clinical Oncology
Type
journal article