Diagnosis of Canine Immune-mediated Hemolytic Anemia and Evaluation of Intravenous Human Immunoglobulin Treatment
Date Issued
2005
Date
2005
Author(s)
Chen, Wan-Chu
DOI
zh-TW
Abstract
Immune-mediated hemolytic anemia (IMHA) is an important immunological disease in dogs. 27 IMHA dogs treated with human intravenous immunoglobulin (hIVIG) were included in this study. The signalments, histories, clinical findings, and blood examinations results of 27 IMHA dogs were collected to understand the present situation of canine IMHA in Taiwan, and evaluated the theraprutic effects of hIVIG. In this study, middle-age females had higher risk for IMHA than males. Maltese and Shih-Tzu were the most affected breeds. The most frequently encountered clinical signs and presentions of physical examination included lethargy, anorexia, pale mucus membrane, icterus, and pigmenturia. Blood examinations presented anemia (100%) which 55.6% were regenerative and 44.4% were non-regenerative, leukocytosis (77.8%), and thrombocytopenia (71.4%) at presenting. Diagnosis of IMHA showed 77.8% with true autoagglutination, 66.7% with positive Coombs’ test, and 19% with spherocytosis. The positive result, type of antibody and titers of Coombs’ tests could not indicate good prognosis, but the therapeutic effects were corresponded with the variation of titer. Survival rate during the 6-month observation period was 63%, and no obvious side effects were observed. The IMHA dog with good prognosis showed the increasing of Hb, PCV, and RBC during 7th day to 14th day, and without or in short time with others immunosuppressive agent after hIVIG therapy. Different concentration of same product didn’t affect therapeutic effect. Another important point was also observed, that hIVIG maybe can decrese severe hemolysis after inappropriate blood transfusion. Therefore, intravenous administration of hIVIG may be a good alternative therapy for canine IMHA.
Subjects
犬
免疫性溶血性貧血
靜脈注射人類免疫球蛋白
dog
immune-mediated hemolytic anemia
inravenous human immunoglobulin
SDGs
Type
thesis
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