Common variants in IGF1 pathway genes and clinical outcomes after radical prostatectomy
Journal
Annals of Surgical Oncology
Journal Volume
20
Journal Issue
7
Pages
2446-2452
Date Issued
2013
Author(s)
Chang C.-F.
Pao J.-B.
Yu C.-C.
Huang S.-P.
Yang Y.-P.
Huang C.-N.
Chang T.-Y.
You B.-J.
Lee H.-Z.
Hour T.-C.
Bao B.-Y.
Abstract
Background: Insulin-like growth factor-1 (IGF1) pathway plays a critical role in malignant transformation, and epidemiology studies have also shown that single nucleotide polymorphisms (SNPs) in IGF1 pathway genes are associated with prostate cancer risk. However, the clinical significance of these SNPs on prostate cancer aggressiveness and prognosis after radical prostatectomy (RP) has not been determined. Methods: We evaluated the associations of 4 common SNPs in IGF1 and IGF1R with age at diagnosis, preoperative prostate-specific antigen (PSA) level, pathologic Gleason score, pathologic stage, surgical margin, lymph node metastasis, and PSA recurrence in a cohort of 320 localized prostate cancer patients receiving RP. The prognostic significance on time to PSA recurrence was also assessed by Cox proportional hazards model. Results: IGF1 rs2946834 alleles/genotypes and an IGF1 specific haplotype AT, containing the minor allele of rs2946834, were associated (P ? 0.028) with a 1.49- to 2.22-fold higher risk of having advanced-stage prostate cancer. In addition, a genetic interaction profile consisting of IGF1 rs2946834 and IGF1R rs2016347 was significantly associated with PSA recurrence (P = 0.033). Conclusions: Our study is the first to evaluate the impact of SNPs in IGF1 pathway genes on PSA recurrence. A genetic interaction between IGF1 rs2946834 and IGF1R rs2016347 might be a predictor of outcomes following RP. ? 2013 Society of Surgical Oncology.
SDGs
Other Subjects
prostate specific antigen; somatomedin C; somatomedin C receptor; adult; age distribution; aged; article; cancer diagnosis; cancer patient; cancer recurrence; cancer risk; cancer staging; cancer surgery; gene frequency; genetic association; genetic variability; genotype; Gleason score; human; human tissue; lymph node metastasis; major clinical study; male; outcome assessment; preoperative evaluation; prostate cancer; prostatectomy; single nucleotide polymorphism; Age Factors; Aged; Haplotypes; Humans; Insulin-Like Growth Factor I; Kaplan-Meier Estimate; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Grading; Neoplasm Staging; Neoplasm, Residual; Polymorphism, Single Nucleotide; Proportional Hazards Models; Prostate-Specific Antigen; Prostatectomy; Prostatic Neoplasms; Receptor, IGF Type 1
Type
journal article