Ultrasonic tissue characterization evaluates myocardial viability and ischemia in patients with coronary artery disease
Journal
Ultrasound in Medicine and Biology
Journal Volume
26
Journal Issue
5
Pages
759-769
Date Issued
2000
Author(s)
Abstract
To evaluate whether or not ultrasonic tissue characterization (UTC) can detect jeopardized or salvageable myocardium in patients having chronic coronary artery disease, we studied 103 patients with sequential UTC, dobutamine stress echocardiography (DSE) and 201thallium stress-reinjection single-photon emission computed tomography (T1-SPECT). This revealed that the weighted amplitude of the cyclic modulation of integrated backscatter was larger for the myocardium with less ischemia burden or greater viability (p < 0.001). The segments with larger ischemia burden or the nonviable myocardium demonstrated the contrary result. Using the receiver-operating characteristic curve analyses to determine the cutoff value of weighted amplitude for various predictions, UTC can detect ischemia in normokinetic myocardium (κ = 0.34 compared to DSE or T1-SPECT) and viability in dyssynergic myocardium (κ = 0.57 compared to DSE and 0.45, to T1-SPECT). These observations show that UTC may prove useful in the identification and pathophysiological understanding of myocardial ischemia and viability. Copyright (C) 2000 World Federation for Ultrasound in Medicine and Biology.To evaluate whether or not ultrasonic tissue characterization (UTC) can detect jeopardized or salvageable myocardium in patients having chronic coronary artery disease, we studied 103 patients with sequential UTC, dobutamine stress echocardiography (DSE) and 201thallium stress-reinjection single-photon emission computed tomography (T1-SPECT). This revealed that the weighted amplitude of the cyclic modulation of integrated backscatter was larger for the myocardium with less ischemia burden or greater viability (p<0.001). The segments with larger ischemia burden or the nonviable myocardium demonstrated the contrary result. Using the receiver-operating characteristic curve analyses to determine the cutoff value of weighted amplitude for various predictions, UTC can detect ischemia in normokinetic myocardium (κ = 0.34 compared to DSE or T1-SPECT) and viability in dyssynergic myocardium (κ = 0.57 compared to DSE and 0.45, to T1-SPECT). These observations show that UTC may prove useful in the identification and pathophysiological understanding of myocardial ischemia and viability.
SDGs
Other Subjects
Blood vessels; Cardiovascular system; Computerized tomography; Diseases; Medical imaging; Physiology; Thallium; Tissue; Coronary artery disease; Dobutamine stress echocardiography; Myocardial variability; Thallium perfusion imaging; Echocardiography; dobutamine; thallium; adult; aged; article; clinical trial; controlled clinical trial; controlled study; coronary artery disease; diagnostic value; female; heart muscle; heart muscle ischemia; human; major clinical study; male; priority journal; stress echocardiography; ultrasound; Cardiotonic Agents; Chronic Disease; Coronary Disease; Dobutamine; Echocardiography; Exercise Test; Female; Humans; Injections, Intravenous; Male; Middle Aged; Myocardial Contraction; Myocardium; ROC Curve; Severity of Illness Index; Thallium Radioisotopes; Tomography, Emission-Computed, Single-Photon
Type
journal article