Poly(glycerol sebacate)-co-poly(ethylene glycol)/Gelatin Hybrid Hydrogels as Biocompatible Biomaterials for Cell Proliferation and Spreading
Journal
Macromolecular Bioscience
Journal Volume
21
Journal Issue
12
Date Issued
2021
Author(s)
Chang C.-W
Abstract
Synthetic polymers have been widely employed to prepare hydrogels for biomedical applications, such as cell culture, drug delivery, and tissue engineering. However, the activity of cells cultured in the synthetic polymer-based hydrogels faces the challenges of limited cell proliferation and spreading compared to cells cultured in natural polymer-based hydrogels. To address this concern, a hybrid hydrogel strategy is demonstrated by incorporating thiolated gelatin (GS) into the norbornene-functionalized poly (glycerol sebacate)-co-polyethylene glycol (Nor_PGS-co-PEG, NPP) network to prepare highly biocompatible NPP/GS_UV hydrogels after the thiol-ene photo-crosslinking reaction. The GS introduces several desirable features (i.e., enhanced water content, enlarged pore size, increased mechanical property, and more cell?adhesion sites) to the NPP/GS_UV hydrogels, facilitating the cell proliferation and spreading inside the network. Thus, the highly biocompatible NPP/GS_UV hydrogels are promising materials for cell encapsulation and tissue engineering applications. Taken together, the hybrid hydrogel strategy is demonstrated as a powerful approach to fabricate hydrogels with a highly friendly environment for cell culture, expanding the biomedical applications of hydrogels. ? 2021 Wiley-VCH GmbH
Subjects
cell proliferation
cell spreading
hybrid hydrogel
poly(glycerol sebacate)
thiol-ene photochemistry
Aliphatic compounds
Biocompatibility
Biomechanics
Cell culture
Cell proliferation
Cells
Crosslinking
Drug delivery
Functional polymers
Glycerol
Hydrogels
Medical applications
Polyethylene glycols
Pore size
Tissue
Tissue engineering
Biomedical applications
Cell encapsulations
Desirable features
Hybrid hydrogels
Photo crosslinking reaction
Polies (glycerolsebacate)
Synthetic polymers
Tissue engineering applications
Cell engineering
SDGs
Type
journal article