One-Pot Synthesis of α,β-Unsaturated γ-Lactones and Lactams via a Sequential trans-Hydroalumination and Catalytic Carboxylation of Propargyl Alcohols and Amines with Carbon Dioxide
Journal
Organic Letters
Journal Volume
22
Journal Issue
6
Pages
2328-2332
Date Issued
2020
Author(s)
Abstract
A one-pot, sequential process that combines a trans-selective hydroalumination of propargyl alcohols and amines with a copper- or silver-catalyzed carboxylation reaction using carbon dioxide, followed by an acid-mediated intramolecular condensation step, led to the formation of a wide range of α,β-unsaturated γ-butyrolactones and lactams. Copyright ? 2020 American Chemical Society.
Subjects
Amides; Amines; Carboxylation; Butyrolactones; Catalytic carboxylation; Hydroalumination; Intramolecular condensation; One pot; One-pot synthesis; Propargyl alcohol; Sequential process; Carbon dioxide
Type
journal article