Validation and Disease Risk Assessment of Previously Reported Genome-Wide Genetic Variants Associated With Brugada Syndrome: SADS-TW BrS Registry
Journal
Circulation. Genomic and precision medicine
Journal Volume
13
Journal Issue
4
Pages
e002797
Date Issued
2020-08
Author(s)
Julius Chen, Ching-Yu
Yu, Qi-You
Sherri Yeh, Shih-Fan
Chuang, Jing-Yuan
Yang, Dun-Hui
Abstract
Brugada syndrome (BrS) is an oligogenic arrhythmic disease with increased risk of sudden cardiac arrest. Several BrS or ECG traits-related single-nucleotide polymorphisms (SNPs) were identified through previous genome-wide association studies in white patients. We aimed to validate these SNPs in BrS patients in the Taiwanese population, assessing the cumulative effect of risk alleles and the BrS-polygenic risk score in predicting cardiac events.
Subjects
Brugada syndrome; genetics; genotype; mutation; risk
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Type
journal article