Re-"Formate" T-cell Antitumor Responses.
Journal
Cancer discovery
Journal Volume
13
Journal Issue
12
Start Page
2507
End Page
2509
ISSN
2159-8290
Date Issued
2023-12-12
Author(s)
Abstract
Rowe and colleagues discover that one-carbon (1C) metabolism rewiring occurs upon T-cell activation to support proliferation and cytolytic activity in CD8+ T cells and that supplementation of 1C donor formate rescues the dysfunctional T cells and their responsiveness to anti-PD-1 in selective tumor-infiltrated T-cell subsets. This finding represents an attractive strategy to overcome a metabolic vulnerability in the tumor microenvironment and improve the efficacy of immune checkpoint blockade. See related article by Rowe et al., p. 2566 (8).
SDGs
Type
journal article