Study on the effect of regulating blood pressure of Monascus purpureus NTU 568 fermented product to mild to moderate hypertension patient in randomized, double-blind clinical trials
Date Issued
2015
Date
2015
Author(s)
Lee, Chih-Heng
Abstract
Hypertension and cardiovascular complications are the leading cause of death of compatriots. Once patients suffer from hypertension, they need long-term monitoring of blood pressure and actively improve the living habits. Even more, take medication to control blood pressure. Antihypertensive drugs usually have side effects, improper use of antihypertensive medications often cause irreparable harm. The application of Monascus species in food, medicine, and industry dates back over a thousand years. Monascus-fermented products containing antihypertensive substance γ-amino butyric acid (GABA), an inhibitory neurotransmitter, can cause blood vessels to dilate. Oral administration of red mold dioscorea fermented by Monascus purpureus NTU 568 to spontaneously hypertensive rats (SHR) for eight weeks has been shown to significantly reduce systolic blood pressure 26 mmHg and diastolic blood pressure 22 mmHg (p<0.05) and will not have liver and kidney damage. In this study, a double-blind placebo-controlled model was undertaken. Patients with mild to moderate hypertension were randomly assigned to placebo and treatment groups. Treatment group was given red mold dioscorea (fermented by M. purpureus NTU 568) for 8 weeks to observe the effect of regulating blood pressure in human clinical trials. The results showed that systolic blood pressure of 4 subjects decreased greater than or equal to 10 mmHg in 11 subjects of treatment group. Systolic blood pressure decreased from 141.6 ± 12.0 to 133.9 ± 14.4 mmHg, the average dropped 7.7 mmHg. Diastolic blood pressure decreased from 91.7 ± 8.1 to 84.8 ± 7.4 mmHg, the average dropped 6.9 mmHg. Diastolic blood pressure of 5 subjects decreased greater than or equal to 10 mmHg in 11 subjects of treatment group. The result showed a significant difference (p<0.05), although there was no significant difference between the placebo and treatment groups. Red mold dioscorea did not cause electrolyte imbalance and damage between liver, kidney and muscle tissue of subjects. The study also found that red mold dioscorea treatment could effectively reduce serum triglycerides and total cholesterol, increase high-density lipoprotein cholesterol, and reduce low-density lipoprotein cholesterol levels to achieve cardiovascular health.
Subjects
Monascus-fermented products
red mold dioscorea
hypertension
γ- amino butyric acid (GABA)
clinical trials
SDGs
Type
thesis
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