Synthesis of thermo-sensitive nanoparticles based on poly(n- isopropylacrylamide-co-((2-dimethylamino) ethyl methacrylate)) copolymer for drug controlled release
Journal
7th Asian-Australasian Conference on Composite Materials 2010
Journal Volume
2
Pages
1210-1213
Date Issued
2010
Author(s)
Abstract
A cationic thermo-responsive nanoparticle based on poly(N- isopropylacrylamide-co-((2-dimethylamino)ethyl methacrylate)) copolymers (poly(NIPA-co-DMAEMA)) was successfully fabricated by the free radical polymerization. The z-average diameter and zeta-potential of the prepared nanoparticles was about 140 nm, and 13.02 mV at 25°C, respectively. The lower critical solution temperature (LCST) of the synthesized nanoparticles was 41°C above which the nanoparticles would undergo the volume phase transition from 140 nm to 100 nm, and the size shrinkage could result in expulsion of encapsulated drugs. Therefore, we used the poly(NIPA-co-DMAEMA) nanoparticles as a vector for the controlled release of a hydrophobic anticancer reagent, 7-ethyl-10-hydroxy-camptothecin (SN-38). The SN-38 encapsulated efficiency and loading content at the SN-38/poly(NIPA-co-DMAEMA) ratio of 1/10 (D/P=1/10) were about 80% and 6.293%, respectively. The SN-38 release profile revealed that the release rate at 42°C (above LCST) was higher than that at 37°C (below LCST), and the release of SN-38 molecules could be controlled by increasing the temperature. Therefore, the nanoparticles based on poly(NIPA-co-DMAEMA) exhibited better temperature sensitivity, and would be an ideal carrier for drug delivery system.
Subjects
Cancer; Controlled release; Dmaema; Pnipa; Thermo-sensitive
SDGs
Other Subjects
Acrylic monomers; Composite materials; Copolymers; Drug delivery; Free radical polymerization; Loading; Nanoparticles; Cancer; Controlled release; Dmaema; Pnipa; Thermo sensitive; Synthesis (chemical)
Publisher
ACCM-7 Organizing Committee
Type
conference paper