Synthesis of dimeric LeX and KH-1 antigens
Date Issued
2009
Date
2009
Author(s)
Tsai, Bin-Ling
Abstract
Among four major classes of macro-biomolecules-nucleic acids, proteins, lipids, and carbohydrates-carbohydrates are the least studied and understood.Carbohydrates and their conjugates are abundantly expressed on the out-surfaces of prokaryotic and eukaryotic cells and involved in various biological event. Especially, the surface of cancer cells frequently display glycans at different levels or with fundamentally different structures in comparison with that of normal cells, including the progression of tumor cell metastasis. Dimeric Lewis X and KH-1 are two tumor-associatedntigens. These antigens are considered as the marker for malignancy and pre-malignancies involving colonic adenocarcinoma. Lewis X dimmer and KH-1 tumor associated antigens can be used to develop carbohydrate-basednticancer vaccines and carbohydrate microarray in diagnosis. However, the structure identification and isolation of homogeneous carbohydrate-based tumor antigen is very difficult, organic synthesis play an important role in glycobiology research. Finally, one-pot strategy was successfully developed to synthesis Lewis X monomer, Lewis X dimer hexasaccharide and KH-1 heptasaccharide analogues.
Subjects
carbohydrate synthesis
one-pot
cancer antigen
dimer Lex
SDGs
Type
thesis
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