Rapid analysis of l-dopa in urine samples using gold nanoelectrode ensembles
Journal
Talanta
Journal Volume
74
Journal Issue
2
Pages
229-234
ISSN
0039-9140
Date Issued
2007-11-30
Author(s)
Abstract
This work describes the application of a three-dimensional gold nanoelectrode ensembles (GNEE) for monitoring l-dopa in standards and human urine samples using flow injection analysis (FIA) with amperometric detection. Analytical results reveal that the GNEE exhibited better electrocatalytic activity than a gold disk or glassy carbon electrode. Under optimal conditions of l-dopa analysis at GNEE, the calibration plot has a linear range of 5-300 ng/mL with a coefficient of variation (CV) of 3.1% in pH 7.0 phosphate buffer saline (PBS, pH 7.0). The detection limit was 3.0 ng/mL for FIA. The high precision and sensitivity of GNEE provides a feasible means of directly determining l-dopa in urine samples.
Subjects
Flow injection analysis
Gold nanoelectrode ensembles
l-Dopa
Voltammetry
SDGs
Publisher
Elsevier B.V.
Type
journal article