Hormonal changes in elderly men with non-insulin-dependent diabetes mellitus and the hormonal relationships to abdominal adiposity
Journal
Gerontology
Journal Volume
40
Journal Issue
5
Pages
260-267
Date Issued
1994
Author(s)
Abstract
To elucidate the hormonal changes in elderly men with non-insulin- depcndent diabetes mellitus (NIDDM) and the hormonal relationship to abdominal adiposity, we measured scrum insulin-like growth factor 1 (IGF-1), T3, T4, TSH. testosterone, LH. and FSH levels, body mass index (BMI), skinfold thickness and waist-to-hip circumference ratio (W/H) in 40 elderly men (aged over 60 years), 20 elderly men with NIDDM (aged over 60 years) and 30 men aged 21-40 years (controls). The results showed that elderly men with and without NIDDM had lower serum T3, testosterone and IGF-1 levels and higher serum LH and FSH levels compared with controls. Elderly men with NIDDM had even lower serum testosterone levels compared with elderly men without NIDDM. Elderly men had a higher W/H ratio compared with controls. Elderly men with NIDDM had a higher W/H ratio, BMI and skinfold thickness than elderly men without NIDDM. Age was positively correlated with the W/H ratio. Serum LH and FSH levels were positively correlated with the W/H ratio, and scrum IGF-1, T3 and testosterone levels were negatively correlated with W/H ratio. Age. serum IGF-1, T3, T4, TSH, LH and FSH levels were not related to BMI or skinfold thickness. Only serum testosterone levels were negatively correlated with BMI or skinfold thickness. In conclusion, elderly men with NIDDM were associated with a marked decrease in serum testosterone levels and an increase of the W/H ratio compared to other groups in addition to the age-associated decrease of serum T3, IGF-1 and testosterone levels and increase of the W/H ratio and serum LH and FSH levels. W/H ratio, a parameter of abdominal adiposity, was associated with changes of serum hormone levels, including IGF-1, testosterone, LH, FSH and T3, to a greater degree than BMI or skinfold thickness. ? 1994 S. Karger AG, Basel.
SDGs
Other Subjects
follitropin; hormone; liothyronine; luteinizing hormone; somatomedin c; testosterone; thyrotropin; thyroxine; adult; age; aged; article; body mass; clinical article; controlled study; follitropin blood level; human; liothyronine blood level; luteinizing hormone blood level; male; non insulin dependent diabetes mellitus; obesity; priority journal; skinfold thickness; testosterone blood level; thyrotropin blood level; thyroxine blood level; Abdomen; Adipose Tissue; Adult; Aged; Aging; Body Constitution; Diabetes Mellitus, Non-Insulin-Dependent; Follicle Stimulating Hormone; Hormones; Human; Insulin-Like Growth Factor I; Luteinizing Hormone; Male; Middle Age; Obesity; Testosterone; Thyrotropin; Thyroxine; Triiodothyronine
Type
journal article